Off-label drugs are drugs that refer to the use of drugs outside the indications listed in the product label. A study shows that in practice geriatric patients were more off labeled indications, one of which was on psychotropic prescription off labels carried out more than 60% for therapy of schizophrenia. Decreased physiological conditions and the presence of multipatology or more than one chronic degenerative disease causing the provision of off-label drugs in the geriatric. The purpose of this study was to determine the description of prescribing off-label drug indications in geriatric patients hospitalized at Dr. Sardjito Hospital. This research is a descriptive observational by using a cross-sectional research design, collecting data on the pattern of prescribing off-label drugs in geriatric patients retrospectively with systematic random sampling method. Collecting data from disease index reports and geriatric patient payment bills for hospitalization in 2016. Data analysis was carried out based on reference to the PIONAS. The results of the study from 320 geriatric patients included in the inclusion criteria there were 59.38% of patients who received off-label medication indications. Based of the 4572 prescription drugs there were 8.12% of drugs included in the category of off-label drugs. Medications that included off-label indications were ranitidine (1.36%), sucralfate (0.50%), lansoprazole (0.88%), omeprazole (0.83%), pantoprazol (0.63%), ondansetron (0.50%), domperidone (0.22%), ceftriaxone (0.74%), sildenafil (0.02%), phenytoin (0.24%), dexamethasone (1.07%), 5-fluorouracil (0.22%), gemsitabine (0.04%), dosetaxel (0.04%), paclitaxel (0.11%), carboplatin (0.13%), and sisplatin (0.58%).