often being identified to fail in endodontic treatment. NaOCl is an irrigation material that can eradicate bacteria in root canal but has toxicity effect, so it can be minimized with alternative material that is the extract of salak pondoh (Salacca Zalacca (Gaerth.)Voss) which has antibacterial compound. Objective: This study was aimed to find out the antibacterial activity of the extract of salak pondoh (Salacca Zalacca (Gaerth.)Voss) in inhibiting the growth of Enterococcus faecalis bacteria. Methodology: This study was laboratory experimental in vitro. Salak Pondoh (Salacca Zalacca (Gaerth.)Voss) fruit is extracted by the method of maceration using 70% ethanol solvent. In the extract which is ready, the antibacterial activity is tested using the well diffusion method. The measurement is done by looking at the inhibition zone around the well. Result: All concentrations of the extract of salak pondoh can inhibit the growth of Enterococcus faecalis bacteria. The higher concentration of the extract of salak pondoh (Salacca Zalacca (Gaerth.)Voss), the higher the inhibition zone produced. Conclusion: The extract of salak pondoh (Salacca Zalacca (Gaerth.)Voss) has an antibacterial power activity in inhibiting the growth of Enterococcus faecalis bacteria. Minimum inhibitory level on administration of extracts is with a concentration of 20%.