Background: Stroke is a health problem that needs special attention. Clinical pathwayimplementation needs to be done in ischemic stroke patients, in order to create service costs and cost efficiency. To determine the implementation, compliance, and obstacles that faced by medical personnel in the implementation of the clinical pathwayof ischemic stroke at PKU Muhammadiyah Gamping Method: This research using mixed method, with sequential explanatory design, for ischemic stroke patients. Research informants are neurologist who handle stroke patients, and medical committee members. Data collection was carried out with medical record documentation and interviews. This research used descriptive and qualitative analysis techniques. Results: The results of the study were mostly male patients, which were 30 people or 56.6%. Based on the highest age, it is 61-70 years, that is 14 people or 26.4%, and the length of treatment is more than 4 days, namely 41 people or 77.4%. Respondents compliance related to the clinical pathways of ischemic stroke were also included in the non-adherent category, which was carried out on 39 patients (73.6%). Conclusion: Implementation of clinical pathways of ischemic stroke is in good category. Compliance with the clinical pathways of ischemic stroke is also included in the non-compliance category. Efforts to carry out these examinations are carried out through the implementation of clinical pathways and the need to establish special stroke units. In this regard, audits and clinical evaluations can be carried routinely. Keywords: Implementation, Compliance, Clinical Pathways, Ischemic Stroke