Background: Hospital services require comprehensive and professional performance of nurses in improving hospital quality, several factors that influence it are good leadership and motivation. The service quality of Pratama Yogyakarta Hospital is still not in line with expectations, which means that some nurses' performance needs to be improved. Method: Type of quantitative research with a cross-sectional approach. The study sample consisted of 58 nurses, determination of sampling with total sampling. The research instrument uses a questionnaire that has been tested for validity and reliability. The questionnaire consists of 60 questions. Data analysis uses multiple linear regression. Result and Discussion: Leadership t test 2.768 with a significance level of 0.008 indicating that leadership influence the performance of nurses. Motivation t test 6.336 with a significance level of 0,000 indicates that motivation influence the performance of nurses. F value of 26.515, significance of 0.000 shows leadership and motivation have a positive and significant influence on nurse performance. Conclussionss: Leadership influence the performance of nurses, motivation influence the performance of nurses, leadership and motivation together have a positive and significant influence the performance of nurses. Keyword: Leadership, Motivation, Performance