This study aims to determine the effect of the regional economic growth based on the variables’ influence, such as regional independence, regional financial performance, and inflation in an area. The type of this research was quantitative research that used in five areas with the largest economic growth in Central Java and Yogjakarta in 2012-2016. The data used secunder data from Badan Pusat Statistik with domestic product data, original income data in area, and rate of inflation. The result showed that there was positive effect and significant between regional independence, regional financial performance, and inflation towards the regional economic growth.