One of the achievements in patient safety is reducing the risk of CAUTI incidents in a hospital by managing, preventing, and controlling the risk of CAUTI. One method to achieve this is by utilizing the CAUTI Bundle. Objective: The purpose of this study was to analyze the comparison of CAUTI prevention in the intervention group and control group after the development of the CAUTI (Post-test only) Methods: This research used a true experimental quantitative method (post-test only) and was carried out for 2 weeks through consecutive sampling. It was found that 64 respondents used urinary catheters in six inpatient rooms. These six inpatient room were divided into two groups, 3 rooms with 32 respondents were the intervention group and 3 other rooms with 32 respondents were the control group. Results: The results of the post-test implementation of CAUTI Bundle showed that in the non-parametic test results of the Mann-Whitney Test, there were significant differences between the intervention groups that were administered CAUTI Bundle and the control group, with a significance of 0.001 <0.05. Conclusion: The level of CAUTI prevention conducted by nurses in the intervention group that implemented CAUTI Bundle was different from the control group. It indicates a difference in nurse's compliance in the implementation of CAUTI prevention.