Social media can dominate the public space from the development of the use of social media from the community itself (Atmodjo, 2014). Nowadays, social media has an important role in influencing all aspects of life, including the political sphere. It also has a significant role in conveying information. In the current era, information is a very important thing that all people need. The purpose of this study is to explain whether there is an influence of social media on students of Social and Political Science of Universitas Muhammadiyah Yogyakarta. This study uses a mixed method between quantitative and qualitative and uses research methods that aim to connect between variables by using the SPSS. The data collection technique in this study employs two types of data sources. The primary data are obtained from the distribution of questionnaires from 114 samples and secondary data are obtained through interviewees. Social media are the focus of research namely Facebook, Twitter and Instagram. The results of this study indicate that social media has a significant influence on the political knowledge of the students of the Faculty of Social and Political Science of the Universitas Muhammadiyah Yogyakarta.