Upper respiratory tract infection (URTI) is one of the biggest factorwhich leads patient to visitthe health facilities, eitherprimary health care or hospital. An effort to reduce the URTI incidences is to provide information about the proper use of antibiotics. Puskesmas Selindung was chosen as the research site, because it’s high incidence of Upper Respiratory Tract Infection on 2014 with 1298 cases and most people still have low awareness onthe adherence ofusing antibiotics for URTI therapy. Based on that problem, giving drug information is considered as an effort to improve patient adherenceon using antibiotics. The aim of this studywas to identify the effect of sociodemographic factors and drug information towardURTI patient adherenceonusing antibiotics in Selindung Primary Health Care, Pangkalpinang City. The study design was used a static-group-comparison design method.60 respondents was involved and divided into 2 groups, intervention group and control group, with consecutive sampling technique, analyzedby statistic test. Mann-Whitney U test showed result with significance score,p value 0.000 (< 0, 05) which means statically different.This study conclude that there was an effect of giving drug information toward URTIpatient adherenceonusing antibiotics and there was no effect of sociodemographic factors (education,age, gender, and job) either on treatment group (received drug information) or controlgroup (not received drug information)toward URTI patient adherenceonusingantibioticsin Selindung Primary Health Care, Pangkalpinang City.