Pneumonia is one of the acute respiratory tract infections that causes the most deaths in children less than five years old (toddlers) in both developing and developed countries. One of the treatments used is antibiotics, but improper use of antibiotics can lead to ineffective therapy and the most dangerous is resistance. This study to describe and evaluate the accuracy of antibiotic therapy in toddlers with pneumonia at the inpatient installation of Yogyakarta City Public Hospital for the period January-December 2017 based on indicators of antibiotic use of the Indonesian Ministry of Health in 2011. This study was an observational descriptive study using cross sectional method with taking Retrospective data through medical records of under-five patients diagnosed with uncomplicated pneumonia at the inpatient installation of Yogyakarta City Hospital in the January-December 2017 period and total sampling techniques by 73 patients who met the inclusion criteria. Data processing was carried out descriptively and compared the use of antibiotics given by the Pharmaceutical Care guidelines for Respiratory Tracts of the Republic of Indonesia (2005), Medical Service Guidelines from IDAI (2009), Revised WHO classification and treatment of childhood pneumonia at health facilities (2014) and Standards Hospital Medical Services (SPM). Antibiotics used for the treatment of toddlers with pneumonia at the inpatient installation of Yogyakarta City Hospital in the period January-December 2017 are single use of ampicillin (8.2%), cefixime (5.5%), cefotaxime (2.8%), ceftriaxone ( 4.1%), and amoxicillin (5.5%). While the use of combination is ampicillin with gentamicin (68.5%), cefotaxime with gentamicin (9.5%), cefixime with ceftriaxone (1.4%), cefixime with amoxicillin (1.4%) and ampicillin with amikacin (2, 7%). The most prescribed antibiotics by doctors were a combination of ampicillin and gentamicin antibiotics, namely 50 patients (68.5%). The results of the analysis in this study were 73 patients (100%) given the right antibiotic indication, the right type and dosage of 32 patients (43.8%), right route 73 patients (100%) and exact duration of administration of 34 patients (46.6 %). So that there were 16 patients who received the right antibiotics (22%) and incorrect antibiotics as many as 57 patients (78%).