Based on Riskesdas 2018, 31.4% of households in Indonesia utilize traditional health services. As the need for traditional medicine increases, the government forms a program called "Saintifikasi Jamu" which serves to elevate herbal medicine into a product that is scientifically proven to be used in health services. The Hortus Medicus Clinic is one of the research clinics that applies traditional medical services based on herbal medicine. Hypertension, diabetes mellitus, hyperuricemia and hypercholesterolemia are 4 diseases with the highest number of patients in 2017 at the Hortus Medicus clinic. This study aims to determine herbal prescribing patterns in hypertension, diabetes mellitus, hyperuricemia, and hypercholesterolemia in the Hortus Medicus Clinic. This study is an observational descriptive study by looking at herbal prescribing patterns in 4 major diseases in the Hortus Medicus Clinic, namely hypertension, diabetes mellitus, hyperuricemia and hypercholesterolemia in 2017 which are adjusted to the standard of service in the Hortus Medicus clinic with a total sample of 505 samples obtained by systematic random sampling method. Data retrieval is done retrospectively by looking at recipes and medical records. The data of this study were analyzed descriptively using percentages in the form of diagrams or tables. The results of this study are prescribing patterns in patients with hypertension consisted of a combination of celery, centella, cat mustache, turmeric, phyllanthus, curcuma, thyme, nutmeg, alyxia and imperata cylindrica as variant 1 is the highest percentage prescribed (23%). The herbal prescribing pattern in patients with diabetes mellitus consists combination of tinospora, syzygium, turmeric, phyllanthus, curcuma and black cumin as variant 5 is the highest percentage prescribed (31%). Herbal prescription patterns in hyperuricemia patients consist of a combination of burahol, caesalpia sappan, sonchus, turmeric, phyllanthus, curcuma, thyme, nutmeg and alyxia as variant 1 is the highest percentage prescribed (41%). The herbal prescribing pattern in hypercholesterolemic patients consists combination of sonchus, gentbak, dutch teak, turmeric, phyllanthus, curcuma, thyme, nutmeg, and alyxia as variant 1 is the highest percentage prescribed (38%).