Fire is an exothermic oxidation reaction that takes place quickly from a fuel accompanied by the emergence of fire / ignition which results in losses in the form of assets, humans, environmental damage and can cause casualties. The cause of the fire is the low public awareness of the danger of fire, the community is not ready to deal with and deal with fire hazards, fire protection systems have not been implemented, facilities and pre facilities for building fire protection systems are inadequate. This study aims to determine the Reliability of Building Safety Systems at PKU Muhammadiyah Bantul Hospital which is expected to be a guideline for building fire systems in other Hospital buildings in Yogyakarta. The method used in this study is by observing and interviewing directly the fire protection system based on the Safety Inspection of Building Fire (SNI Pd-T-11-2005-C). The results of this study obtained the Reliability of Building Safety Systems on Site Completion components of 15.875% (Less), Rescue Facilities of 16.6% (Less), Active Protection System of 7.848% (Less), and Passive Protection System of 15.912% (Less). The results of the calculation of KSKB parameters obtained by the Reliability of Building Safety Systems amounted to 56.23% or in the category of Less "K". Based on the results of research at PKU Muhammadiyah Hospital in Bantul, it has not been able to become a guideline for the implementation of fire protection systems in buildings.