The purpose of this study was to explore and to assess the settlings and the completeness of fire protection system facilities at the E6 and E7 lecture buildings of Muhammadiyah University of Yogyakarta, whether they are in accordance with the relevant regulations or not. Fire is a disaster that causes moral and material loss which happens because of an uncontrollable flame. The causes of building fires that often occur in Indonesia are short circuits of electronic devices, electrical short circuits and even human negligence. Fire protection systems in buildings are one of the efforts to minimize the occurrence of large fires and to minimize the losses obtained. This study used the reference PD-T-11-2005-C with an observation analysis method in the field. The results of the study showed that the reliability value of the building safety systems of buildings E6 and E7 was 85.65%. This value indicates that the completeness and settlings of protection system infrastructure facilities in Building E6 and E7 of Muhammadiyah Yogyakarta University are good and in accordance with the regulations.