The aim of this research is to analyse the protection of persons with intellectual disabilities in the Special Region of Yogyakarta and the actual implementation of the Regional Regulation of Special Region of Yogyakarta Province Number 4 of 2012 on the Protection and Fulfilment of the Rights of Persons with Disabilities and other regulations in each region on the issue of disability. The methodology used in this research is normative as well as empirical legal research. This research uses primary data which is obtained by conducting field research through interviews with selected respondents and supported by data from literature research. The result of this research shows that the government of the Special Region of Yogyakarta has already implemented some initiatives in providing protection of the rights of persons with intellectual disabilities through the enactment of regional regulations in each region. However, these regulations are not sufficient in covering every aspect of the rights of persons with intellectual disabilities and considered outdated in meeting the standard to protect and accommodate persons with intellectual disabilities in the present. The implementation itself also is still lacking due to the lack of budget, facilities, infrastructures and lack of awareness on the issue of disabilities. Thus, it is highly recommended for the government to amend the Regional Regulation of Special Region of Yogyakarta Province Number 4 of 2012, especially on the matter of women and children with disabilities. Also to put more attention on the implementation of such regulations by increasing the budget allocated for protecting and accommodating the needs of persons with intellectual disabilities and improve its efforts in generating more public awareness on the issue of disabilities and for the persons with intellectual disabilities to be more outspoken regarding their rights in order to pressure the government to provide adequate protection for them.