Urinary Tract Infection (UTI) is an infection in the human urinary tract caused by the growth of microorganisms. UTI sufferers in Indonesia reach 90-100 cases per 100.000 population per year. The primary therapy in urinary tract infections is antibiotics, but the improper use of antibiotics can lead to antibiotic resistance and unwanted drug effects. In 2017, there were 415 pediatric patients in the inpatient installation of PKU Muhammadiyah Hospital Bantul diagnosed with UTIs. The purpose of this research is to evaluate use of antibiotics in the treatment of urinary tract infections to pediatric patients in the inpatient installation of PKU Muhammadiyah Hospital in Bantul, the period of January to December 2017. This research is the descriptive research with cross sectional. Samples are taken from populations with the inclusion criteria using the purposive sampling method. The sampling quantity is measured using the Slovin formula. On this research, the data come from 100 patient medical records based on inclusion criteria. The most used antibiotics are cephalosporins includes cefotaxime (36%), Cefadroxil (33%), Ceftriaxone (14%), Cefixime (13%), and Ampicillin (2%) Amoxicylin (2%) from the penicillin class. The use of antibiotics is analyzed based on these criteria: appropriate indication (100)%, appropriate medication (100%), and the appropriate dose (86%).