Mental disorders are health problems that need to be discussed. The most common mental disorder is schizophrenia. In 2013 the Special Region of Yogyakarta (DIY) became one of the provinces with the highest prevalence of severe mental disorders (schizophrenia) in Indonesia. This disease requires antipsychotic therapy in a long period of time, it is very possible that the treatment process can be found in the use of antipsychotics. This study was conducted to determine the pattern of antipsychotic use in schizophrenia patients at Grhasia General Hospital Yogyakarta and to evaluate the evaluation of antipsychotic therapies and side effects caused by patients in these hospitals. This research was conducted using a descriptive design with retrospective data collection by looking at medical record data in patients diagnosed with schizophrenia for the 2017 period, which was cross sectional. The sampling technique used was simple random sampling with a sample of 64 patients who met the study inclusion criteria. Antipsychotic treatment data obtained related to the accuracy of the indication, the accuracy of the patient, the accuracy of the drug, the accuracy of the dose, the accuracy of the frequency, and alert to side effects. The data is then presented descriptively in the form of a percentage. The results showed that the use of antipsychotic drugs in schizophrenic patients at Grhasia Mental Hospital Yogyakarta in the 2017 period of therapy was Risperidon 3.1% and combination of Clozapin with Risperidon 35%. The results of the analysis of the accuracy of the use of antipsychotic drugs in schizophrenic patients at Grhasia Mental Hospital Yogyakarta period 2017 showed 100% indication accuracy, 100% patient accuracy, 82.8% accuracy of drugs, 98.6% dose accuracy, 98.6% frequency accuracy. The description of the occurrence of side effects of the use of antipsychotic drugs that appeared in Grhasia Yogyakarta Hospital in 2017 for 3 patients 5% was approved by hypersalivation and tremor which are extrapyramidal phenomena.