Vital signs are basic information about a person's vital organs, consist of blood pressure (NIBP), heart rate (BPM), respiration rate, and body temperature. These vital signs need to be monitored continuously to find out the patient's condition, but in its application to monitor respiration is still counted manually by nurses probably causes human error. At the same time monitoring temperature still uses a thermometer, so that measurement is done separately from the other parameters. This Vital Signs system is currently using the DS18B20 as the sensor to read the patient's body temperature and the flex sensor to read the respiration patient’s in one minute (breath per minute). This data processing uses the Arduino Mega microcontroller, while the visual output uses a TFT LCD. Temperature parameter testing is done by comparing the device module with a thermometer, while the respiration parameters are compared with the measurement of the respiration rate manually for one minute. The results of temperature parameter calibration have a percentage error value of 1.2495%. While the respiration parameter has a percentage error value of 5.2378%. From the calibration on the temperature parameters the device module works well because it does not exceed the tolerance value of 5%. Whereas the respiration parameter was declared successful in monitoring the respiration rate but the sensor was too sensitive so it produced a value that was not so well.