Background: Dentist is one of the health professions that has the potential to have a high level of burnout. A dentist with a high tendency to burnout can reduce the health, causing boredom, and affecting the work professionalism. This research aims to analyze the influence of work engagement and religiosity on burnout levels in dentists. Method: This research uses quantitative data, conducted in Yogyakarta, from August 15–September 15 2019. The technique used purposive sampling method, with the sample inclusion criteria as follow: the dentists working at Klinik Pratama (Primary Health Care) in Sleman, Bantul, and Yogyakarta City; the clinic has collaborated with BPJS (Indonesian Social Insurance Administration Organization); and has been working for more than a year, with the total hours of practice ≥ 50 hours in a month. For the instrument, this research used questionnaires which referred to the UWES (Utretch Work Engagement Scale), MBI (Maslach Burnout Inventory), and also religiosity questionnaires which were distributed in the form of e-questionnaires using the Google Form application. The statistical analysis used multivariate analysis with multiple regression. Result and Discussion: There were 76 dentists as the respondents. The statistical result of the t-test variable of the work engagement with burnout in the dentists was with a significance level of 0.001. There was an influence of the work engagement with burnout on the dentists with negative direction. As for the religiosity with burnout on the dentists was with a significance level of 0.035 because the significance of ≤ 0.05 means that there was an influence between the religiosity with burnout on the dentists. The F test result was with a significance of 0.000. The variables of work engagement and religiosity, altogether, affected the burnout on the dentists, negatively. Conclusion: The work engagement influences the burnout level on the dentists, negatively and significantly. The same goes to the religiosity. The work engagement and the religiosity, together they significantly influence the burnout on the dentists at Klinik Pratama in Sleman, Bantul, and Yogyakarta.