Asthma is a non-communicable disease with chronic inflammation of the airways that involves many cells and elements. AsthmaDroid application is an application that contains basic education about asthma (which includes a brief description of asthma, signs and symptoms, causes and aggravating factors, pharmacological and non-pharmacological treatments, prevention methods, supportive therapy, etc.), notes regarding future action plans (Asthma Action Plan), tests regarding the patient's asthma control (Asthma Control Test), as well as the latest news about the current respiratory health conditions. The aim of this research is to explain the influence of perceived usefulness and perceived ease of use to user acceptance of AsmaDroid applications using the technology acceptance model (TAM). This type of research is a descriptive study with a quantitative approach. Samples taken as many as 100 respondens users of the application AsmaDroid. In taking the sample by using purposive sampling, with the criteria of respondens as students of Universitas Muhammadiyah Yogyakarta who have a history of asthma and have used the AsmaDroid application for at least 1 month. Data analysis technique used is descriptive analysis, with using statistical calculation of multiple linier regression and hypotesis testing using SPSS. From the testing SPSS regression equation that is Y= 0,512 + 0,341X1 + 0,198X2 + e. The result of this research showed that all hypotesis were statistically significant (P-Value<0,05). Perceived usefulness has a positive and significant effect on user acceptance with a significant value of 0,000 <0.05. Perceived ease of use has a positive and significant effect on user acceptance with a significant value of 0.003 <0.005. Based on the results of study concluded that the AsmaDroid application provides benefits and convenience for users so that users accept using the AsmaDroid application as an alternative to monitoring asthma symptoms.