Background : Tuberculosis still a global health problem. The case of tuberculosis in Indonesia is still a frightening threat to the people of Indonesia. In Sleman Regency the discovery of new cases of BTA (+) in 2017 was 372 cases and in 2018 it increased to 443 cases of all types (pulmonary TB and extra pulmonary). The highest number of tuberculosis cases is in Sleman regency, precisely in Depok III Health Center, Berbah Health Center, Sleman Health Center, Mlati II Health Center, and Kalasan Health Center. This tuberculosis can cause several physiological, psychological, and sociological effects that cause depression. Objective: To describe depressions in tuberculosis patients in Sleman. Method: The research design used in this study is qualitative research using a qualitative design, phenomenological approach. Sampling is done using purposive sampling technique. Results: The results of this study indicate that there is a picture of depression in tuberculosis patients in Sleman that can be seen from psychological symptoms, physical symptoms, and social symptoms that appear. Some of factors that influence the occurrence of depression in tuberculosis patients are influenced by the perception of TB, internal factors such as feeling disappointed in the Sang Pencipta and comorbidities, and external factors in the form of losing a job, feeling shunned by family and family support. Conclusion: This study found 2 themes of the emergence of depressive symptoms in TB patients and factors that influence depression in TB patients. From this study showed a description of depression in TB patients consisting of physical, psychological and social symptoms and the presence of factors that influence patients increasingly depressed, namely perceptions of TB, internal factors and external factors. Suggestion: For the next researcher, it is expected to conduct research on efforts to prevent depression in tuberculosis patients so that they can complement the results of this study.