Hypertension is a disease of high blood pressure with systolic blood pressure ≥ 140 mmHg and / or diastolic blood pressure ≥ 90 mmHg. Handling hypertension is done by giving antihypertensive to control blood pressure. Treatment of hypertension that is carried out for a long time even for life makes the economic burden for sufferers and health care providers. The availability of various types of antihypertension requires the selection of effective antihypertensive agents. This encourages the study of Cost Effectiveness Analysis to find out the most effective antihypertensive drugs in terms of benefits and costs so that they can benefit patients. This study was conducted to determine the cost-effectiveness of antihypertensive Captopril compared with Amlodipine in primary hypertensive patients at Wates Public Health Center. The research was a non-experimental observational study with a cohort design with retrospective data collection using medical records at Wates Health Center. The samples obtained were 157 patients consisting of Captopril 12.5 mg 25 patients, Captopril 25 mg 4 patients, Amlodipin 5 mg 97 patients and Amlodipine 10 mg 31 patients. The results showed, from the value of ACER Captopril 25 mg absolute cost effective than Amlodipine 5 mg and Amlodipine 10 mg, Captopril 12.5 mg is absolutely more cost effective than Amlodipine 10 mg while the ratio of Captopril 12.5 and Amlodipine 5 mg have ICER values Rp.128.39.