Health is a human right and one of the elements of prosperity that must be achieved according to the ideals of the Indonesian nation as mandated in the Law No. 36 of 2009 concerning Health. However, in its implementation, health services are still not relatively optimal, especially for people living in Underdeveloped, Border, and Islands Regions (DTPK). People living in DTPK generally have difficulty accessing quality primary health services. Pharmaceutical services play an important role as one aspect of health services. This research aims to find out the performance of clinical pharmacy services based on Rules of Minister of Health Number 74 Year 2016 on Pharmaceutical Service Standards in Puskesmas (Health Center) and to know the influence between the number of pharmacists and health center categories on the performance of clinical pharmacy services in Sebatik Island Health Centers, Nunukan Regency, North Kalimantan Province. This research is a descriptive-correlative study with a quantitative approach carried out in all Sebatik Island Health Centers, Nunukan Regency, North Kalimantan Province, including Sungai Nyamuk Health Center, Aji Kuning Health Center, Setabu Health Center, Sungai Taiwan Health Center, and Lapri Health Center. The data was analyzed based on 7 aspects of clinical pharmacy services consisting of assessment and prescription services, drug information service, counseling, patient visit, drug side effects monitoring, drug therapy monitoring, and the use of medicine evaluation. Data collection is done by observation using list of viewers, questionnaire, and interview, equipped with retrospective data through documentary examination to give a clear depiction. The results showed that the performance of clinical pharmacy services at Sebatik Island Health Centers in Nunukan Regency North Kalimantan Province, was 0 aspect (0%) is in very high criteria, 2 aspects (29%) are in high criteria, 0 aspect (0%) is medium criteria, 2 aspects (29%) are low criteria, and 3 aspects (43%) are in very low criteria. The average performance of clinical pharmacy services due to the assessment of the seven aspects is 52% or considered as low. There is no significant correlation between the influence of the number of pharmacists and the category of health center with the performance of clinical pharmacy services in Sebatik Island Health Centers, Nunukan Regency, North Kalimantan Province.