The present research describes problematics of ASEAN in handling transnational crime about narcotics smuggling in Southeast Asia. Southeast Asia is a region in the world spreading in area of 4.4 million square kilometres. Based on population data by United Nations Department of Economic and Social Affairs, the population of ASEAN has increased from 563.7 million in 2006 to 631.8 million in 2015 at a rate of 1.14% per annum. With the big potency countries in Southeast Asia region faces narcotics as one of the most dangerous threats for human security that has increasing trends and pattern and provides depraved effect for human security in Southeast Asia. The method used in this research was a qualitative method and the research was conducted in Southeast Asia region and the data were collected from books, encyclopaedias, journals, mass media and websites as well as in-depth interviews with the ASEAN Secretary. Moreover, this research used constructivism approach and human security, transnational crimes, international regimes, model of negotiations in International Regimes and narcotics as theoretical concepts. The result of this research shows that some factors caused the failure of international security regimes of ASEAN toward handled of Transnational Crime about Narcotics Smuggling in Southeast Asia Region that is negotiating factors in international scopes namely different perception about narcotics threat between ASEAN members, different priority interest of ASEAN leader members, weakness in values and principles of ASEAN and there is no a guiding state to control ASEAN consensus also no sense of belonging of ASEAN society toward ASEAN. Besides that, negotiation process at member states level starting from ratification until law enforcement, acceleration method of narcotics smuggling by transnational crime actors, new types of narcotics and geographical territories of ASEAN are factors effecting ASEAN in handling transnational crime in form of narcotics smuggling in Southeast Asia.