The purpose this study was to knew the influence of job satisfaction and job stress to work deviant behavior in Muhammadiyah University of Yogyakarta employees. The research is qualitative and the data collection is done by distributing questionnaires , the samples in this research using census sampling with 88 respondents. Data analysis techniques using multiple linier regression tests. The results of this research showed that job satisfaction negative impact on work deviant behavior and job stress have positive impact on work deviant behavior.