Background: Samudra Husada Mother and Child Hospital is a Class C private hospital that has implemented a remuneration system for the first time. Hospitals are required to serve the community well so that it requires good employee performance and productivity. Quality Human Resources can create good performance and good employee performance will increase productivity for the organization. This study aims to analyze the Effect of Satisfaction, Compensation and Motivation on Employee Performance at RSIA Samudra Husada Magetan. Method: The method-used was Quantitave. The independent variables were work satisfaction and compensation, the dependent variable was work performance, and the intervening variable was work motivation. The population of this research, accounting for 70 people. The research technique was using Convenience sampling. Result and discussions: The result was based on P Values 0.000 ( < P Values 0.05 ) and the original sample value at 0.487, so the First Hypothesis was accepted. According P Values 0.000 (>0,05) and the original sample value at 0.451, so the Second Hypothesis was accepted. According to P Values 0.000 (<0,05) and R Square value at 0.793, the Third Hypothesis was accepted. P Values 0.001 (>0,05) and the original sample value at 0.733, the Fourth Hypothesis was accepted. P Values 0.202 (<0,05) and the original sample value at -0.353, the Fifth Hypothesis was rejected. P Values 0.222 (<0,05) and the original sample 0.262, so the Sixth Hypothesis was rejected. P Values 0.000 (<0,05) and the R Square value at 0.486, so the Seventh Hypothesis was accepted. Conclusions: Satisfaction is very influential on the performance of employees of RSIA Samudra Husada, but for Compensation and Motivation does not affect the performance of employees at RSIA Samudra Husada.