Background: Cardiovascular reactivity is the response of the cardiovascular system when reacting to physical stress or psychological stress that can affect hemodynamics. Murottal therapy as a complementary treatment to reduce high blood pressure and efficient therapy, and easily applied by each individual. Purpose: To determine the effectiveness of Al-Qur'an murottal therapy in reducing cardiovascular reactivity on handgrip in pre-elderly hypertension. Method: The design of this research is quasy experiment pretest-posttest non equivalent control group. The sampling technique is non probability sampling (nonrandom) with a quota sampling technique of 60 hypertensive pralansia grouped in a nonrandom (n = 30) intervention group (odd number) and (n = 30) control group. The study subjects were given isometric handgrip test for 3 minutes and measured after a rest period of 5 minutes from the test, then given murottal Al-Qur'an letter Ar-Rahman letter for 15 minutes for 3 consecutive days and evaluated on blood pressure variables, pulse, and MAP with digital tensimeter. Data were analyzed by Independent T-Test. Result: The two groups did not differ significantly in characteristics. The response to increased systolic blood pressure was significantly higher for cardiovascular reactivity to the handgrip with a p-value <0.05. The group given murottal Al-Qur'an therapy showed a significant positive response to a decrease in systolic blood pressure (delta 2,97 ± 8,34 mm Hg vs delta 3,50 ± 9,96 mm Hg; p-value = 0,000), diastolic blood pressure (delta -7,07 ± 6,85 mm Hg vs delta 0,30 ± 7,56 mm Hg; p-value = 0,000), and MAP (delta -9,26 ± 5,81 vs delta 1,25 ± 6,88 mm Hg; p-value=0,000) to cardiovascular reactivity but not to the pulse (p -value> 0.05). Conclusion: Murottal Al-Qur'an therapy can reduce systolic blood pressure, diastolic blood pressure, and MAP on cardiovascular reactivity on handgrip in pre-elderly hypertension.