Cardiovascular disease (CVD) is the number one cause of death in the world, which is estimated to claim 17.9 billion lives each year. Four out of 5 deaths from CVD are caused by heart attack and stroke, one third of those deaths occur under the age of 70.Traditional risk factors such as smoking, hypertension, diabetes, dyslipidemia are reported to affect only 50% of the prevalence and degree of coronary heart disease. Researchers have demonstrated other non-traditional risk factors for CVD; fibrinogen, homocysteine, tissue plasminogen activator (t-PA), and lipoprotein (a) It is also interesting that higher Lp (a) levels also trigger coronary thrombus and restenosis after ballon angioplasty intervention. This study aims to determine the relationship between Lp (a) levels and the presence of coronary thrombus in coronary heart disease patients at Dr. Sardjito Yogyakarta.This is a cross-sectional study. Study subjects were patients aged 20-60 years who underwent coronary angiography for STEMI, NSTEMI, unstable angina pectoris, and stable angina pectoris. The correlation between Lp (a) levels and the presence or absence of thrombus was tested using the Chi square test. The research subjects were 77 subjects (60 men and 17 women). The results showed differences in Lp(a) levels in subjects with coronary thrombus, although not statistically significant.