Background : Burns is the occurrence of tissue damage or loss due to contact with heat sources, which often occurs in everyday life, specifically IIA-degree burns. There is a natural ingredient that is fast and easy to get and also grows around us that could be an alternative medicine namely iler plant (Plectranthus scutellarioides [L.] R.Br. folium). The contents of iler leaf extract (Plectranthus scutellarioides [L.] R.Br. folium) such as the essential oils, flavonoids, and tannins could be used as wound medicine. Objective : To discover the effects of iler leaf (Plectranthus scutellarioides [L.] R.Br. folium) ethanol extract ointment application on the healing process (diameter) of burn injury (Vulnus combutio) grade IIA on white mouse (Rattus norvegicus) wistar strain. Method : This research is an experimental study with a cohort prospective design. The samples used were 30 white mice (Rattus norvegicus) wistar strain which divided into 5 group, the intervention group (2,5%, 5%, and 10% concentration), positive control group, and negative control group. Sibro ointments were given to the positive control group, the negative control group was given a solution of NaCl 0,9%, and the intervention group was given the iler leaf ethanol extract ointment (Plectranthus scuttelarioides [L.] R.Br. folium) with 2,5%, 5%, and 10% concentrations. Measurements were done every two days for 21 days. Results : Data analysis using the Friedman analysis test obtained a p significance value <0.001, this shows that the data is significant. Conclusion : There is an effect of iler leaf extract ointment application (Plectranthus scutellarioides [L.] R.Br. folium) with concentrations of 2,5%, 5%, and 10% in the healing process of grade IIA burns.