E-commerce is an electronic process in which individuals or organizations conduct transactions, buy, sell, transfer, or exchange products, services and or information. E-commerce has many benefits that add to the level of customer satisfaction and also in the things that make customers more attractive. Customer satisfaction is established to create customer loyalty. In this study selected customer loyalty to present actual behavior as a consequence of E-CRM and E-Service Quality (E-SQ) performance. The main purpose of this research is to know the relationship between E-CRM and E-SQ to customer loyalty, where customer satisfaction as focus on e-commerce customer in Yogyakarta. This research method is to survey directly to the customer concerned. Conducted test Reliability and Validity test Servqual instruments. The study respondents consisted of 200 customers. the collected data was analyzed by SEM AMOS method. The results show that: 1) E-CRM does not have a significant effect on customer loyalty; 1) E-SQ does not fill customer loyalty; 3) E-CRM has a significant effect on customer satisfaction; 4) E-SQ has a significant effect on customer satisfaction; 5) Customer satisfaction has a significant effect on customer loyalty; 6) Customer satisfaction as mediating between E-CRM and E-SQ on customer loyalty. Keywords: E-CRM, E-SQ, customer satisfaction, customer loyalty, e-commerce