This study aims to determine the effect of work stress on job involvement partially, the influence of job involvement on turnover intention partially, the effect of work stress on turnover intention partially, how much direct influence of work stress on turnover intention with the indirect effect of work stress on turnover intention through job involvement. This research was conducted at PKU Muhammadiyah Hospital in Yogyakarta. The number of samples from this study were 125 nurses at PKU Muhammadiyah Yogyakarta Hospital. Data analysis using Structural Equation Modeling (SEM) with AMOS 22. The results of this study indicate that work stress affects job involvement partially, job involvement affects turnover intention partially, work stress affects turnover intention partially. The effect of work stress on turnover intention is greater than the indirect effect of work stress on turnover intention through job involvement.