In the last decade, research and studies emerged that deepened and focused on the values of work spirituality, which broadly supported employees to interpret more deeply about their work, so that it was even better in their work assignments. The dimensions of work spirituality are considered to make individuals more productive, understanding more about the meaning of work will produce better performance. The main objective of this study was to examine the relationship between work spirituality, employee performance, organizational commitment, and work involvement. Employees of PKU Muhammadiyah Yogyakarta Hospital were selected as samples in this study. Hospital employees were chosen because hospital service employees were considered capable of understanding more about their work. This research method is by a direct survey to employees. The research respondents consisted of 180 consumers, the data collected was analyzed by the AMOS SEM method. The results showed that: 1) Workplace Spirituality had a positive and significant effect on Organizational Commitment; 2) Workplace spirituality has a positive and significant effect on Job Involvement; 3) Workplace Spirituality has a positive and significant effect on Job Performance; 4) Organizational Commitment has a positive and significant effect on Job Performance; 5) Job Involvement does not have a positive and significant effect on Job Performance.