Pharmacy is one type of business in the sector of medicine that is in need of data processing to simplify and speed up the performance. In the present, there is so many entry data done by manually. A lot of pharmacies are still empowering human to process the data that exist in order to expedite business. Processes that are still passed manually make the performance of the pharmacy to be less effective and efficient. But usually the incoming data will be recorded into a book, this job record is not easy and in addition to the time is also very draining. In addition, the preparation of data on existing pharmacies will also be hampered by the way of management that is still manual. In the make of reports for the evaluation of the performance pharmacies are also experiencing constraints. Therefore, it is necessary to make improvements in the management of a data processing system and preparation of reports. Improvements that will be made is to create a manual recording system using a computer-based system, both in terms of inventory data collection, recording transaction data, the process of making reports and other processes associated with the activities at the pharmacy concerned. With the existence of an information system application data processing and preparation of reports on the pharmacy to be made this, the pharmacy information system will be managed better. Bases on the results of testing with black box on information system Kresna Pharmacy can conclude that this information system can simplify the process of data processing and can facilitate the process of transaction with the customer. This can be as a support to update the system that currently exists in Kresna Pharmacy