Drug abuser can damage the lives of families, communities, and themselves. In Indonesia, adolescent drug abusers are estimated to reach 70%. Therefore, this study aimed to explain the factors that cause adolescents to abuse drugs, to describe patterns of social interaction and religious behavior of adolescents when using drugs and after not using drugs. This study was descriptive research using qualitative approach through in-depth interviews with adolescent drug abusers, and caregivers of Tetirah Dzikir rehabilitation boarding house, Berbah, Sleman, Yogyakarta. The results revealed that there are two factors causing adolescent abusing drugs, namely internal and internal factors. External factors include disharmony in families and families that are not intact. While the internal factor or from their self is curiosity. A good interaction did not occur in social interaction of adolescent abusing drugs when using drugs. Their behaviors tended to be in negative things and they did not perform any worship. In another hand, there are changes after the rehabilitation. The adolescents showed a better pattern of interaction and worship well.