This research aims to: (1) Analyzing transformational leadership of Headmasters of Muhammadiyah Vocational High School (SMK M) Prambanan in increasing human resources quality in three different leadership period, (2) Identifying the transformation of human resources in SMK Muhammadiyah Prambanan. The research approach used here is descriptive analytical qualitative. The reseach took place in SMK Muhammadiyah Prambanan Sleman Regency, Special Region of Yogyakarta. The data collection techniques used were observation, in-depth interview and documentations. Data analysis techniques use the Miles and Huberman models with 4 stages. Based on the results, the writer can conclude: (1) Transformational leadership conducted by the headmasters of Muhammadiyah Vocational High School (SMK M) Prambanan increasing human resources quality in three different leadership period is by changing in the institution’s potential into energy to increase teacher’s quality that has direct implications on increasing students’ quality to improve the school education quality. (2) Different transformation conducted by the headmasters in three different leadership periods is by maximizing the leadership role in increasing human resources quality, in planning the future, and developing new ideas. These actions are conducted in very good ways, namely: communicating vision, developing the culture of quality, and empowering the teachers, Who synergizes with the government and Muhammadiyah Organization as well for the the professionalism area of its main teacher. Key words : Leadership, Transformational, Headmaster, Quality of Education