This study aims to analyze the effect of net profit margin, total asset turnover, activity ratio on company profitability. The object of the study uses manufacturing companies listed on the Indonesia Stock Exchange for the period 2015-2017. Samples were selected using purposive sampling method with a number of 303. The data analysis technique used was multiple linear regression analysis. The results showed that the net profit margin, total asset turnover, activity had a significant positive effect on the company's economic profitability.