The purpose of this research is to analyse the influence of profitability, firm’s size, likuidity, and business risk of the capital structure. Object of this research is used the manufacturing sector listed in Indonesian Stock Exchange (IDX) in the period 2015-2018. Samples were selected by purposive sampling method with 156 samples. The data analysis technique of this research using multiple regression analysis with SPSS 21.0 program. The result showed that profitability and business risk has negative significant effect on the capital structure, firm’s size has positive significant effect on the capital structure, and likuidity has no significant effect on the capital structure.