Diarrhea is one of the health problems in developing countries such as Indonesia. Especially in province of Yogyakarta, diarrhea has the first ranked in the top 10 most diseases inpatients at hospitals based on 2017 health profile data. Results from basic health research finds the fact that from year to year diarrhea is still the leading cause of infant death in Indonesia. It is because it does not perform proper treatment both in the home and in health facilities. Therefore, the aim of this research are to see the patient's treatment profile, tracing the suitability between diarrhea drugs administered by the Standard of Medical Service (SPM) diarrhea, knowing the length of time of stay between groups given a combination therapy of antibiotics and zinc with a group that is only given antibiotics, zinc only, and those are not given therapy both in children diarrhoea patients age 0 months to 5 years in hospital of PKU Muhammadiyah Gamping Yogyakarta at 2018. Design of this research is observational study of non-experimental descriptive methods with the process of taking data is cross sectional methods that are traced retrospectively from the patient's medical record. The total population is 194 patients with a minimum sample of 131 people. Data analysis is performed using a statistical descriptive method that calculates the percentage and the average value of each evaluation result using an application in a computer program. The result is known that the most medicines administered by the drug group are of antidiarrhoea (27.33%), then the dosage form is injection (32.70%), and through the peroral route (45.94%). Based on the results of analysis of suitability between drugs given with SPM diarrhea, 97% of diarrhea patients with dehydration were given rehydration solutions, then 94.5% of diarrhea patients with bacterial infections received rehydration solutions and antibiotics therapy. The smallest length of stay (2.20 days) was shown in patients who received zinc therapy without antibiotics, but statistically there were no significant differences between the therapy groups.