Nursing manager has important roles and responsibilities in carrying out the duty in a hospital, by which high stress level is inevitable. Stress management plays significant role so that work stress is not negatively affecting the nursing manager. Low stress management is potentially increasing the turnover intention. Furthermore, stress management has effect on the nursing manager‟s work motivation, which eventually affects the turnover intention. This research aims to analyze the effect of stress management on work motivation and turnover intention. This research was quantitative with cross sectional design. The subjects of this research involved 33 nursing managers in RSUD KRT. Setjonegoro Wonosobo. The data collection technique was conducted by questionnaire distribution. The analysis technique was regression and path analysis. The research result shows that there is effect of stress management on work motivation, with t-count of 2.300 and p of 0.028 (p<0.05). There is effect of stress management on turnover intention, with t-count of -2.441 and p of 0.021 (p<0.05). There is effect of work motivation on turnover intention, with t-count -3.437 and p 0.002 (p<0.05). The direct effect of stress management on turnover intention is higher than the indirect effect through work motivation(-0.346 > -0.186). Therefore, the effect of stress management on turnover intention is direct.