This research aims to analyze the influence of work-family conflict and family-work conflict to organizational commitment: mediated by job-satisfaction study on female nurses in RSUD Tidar Kota Magelang. Subject in this research was married female nurses in RSUD Tidar Kota Magelang. In this research, the sample used 109 respondents were selected using purposive sampling. Data analysis technique used SEM (Structural Equation Modeling) with AMOS vesion 22 software. Based on the analysis that have been made the results the influence of work-family conflict to job-satisfaction were negative significant. Family-work conflict to job-satisfaction were negative not significant. Work-family conflict to organizational commitment were negative significant. Family-work conflict to organizational commitment were negative not significant, job-satisfaction to organizational commitment were positive significant, work-family conflict to organizational commitment were significant through mediation of job-satisfaction, and family-work conflict to organizational commitment were not significant through mediation of job-satisfaction of female nurses in RSUD Tidar Kota Magelang