This research aims to analyze the influence of placement and employee motivation towards performance on The Regional Secretary of Kulon Progo Regency with variable job satisfaction as mediating variable. The number of samples used in the study is as much as 130 respondents, all of the respondents was a clerk in The Regional Secretary of Kulon Progo Regency. Data was analyzed using descriptive and quantitative approach. A descriptive analysis was carried out by manual, whereas quantitative analysis using Smart-PLS. The results show that : placement of employees have significant positive influence on performance, placement of employees have significant positive influence towards job satisfaction, job satisfaction did not significantly to performance, motivation of employees has a significant positive influence on performance, motivation of employees has a positive influence towards job satisfaction, job satisfaction does not mediate the placement of employees on performance, and then job satisfaction does not mediate the motivation of working on performance.