Rapid Prototyping based on fused deposition modeling (FDM) is widely used as the technology on additive manufacturing kit or 3D printing. The process of FDM product fabrication was used the layer-by-layer technique with benefits to produce any complex 3D parts. Filament Polylactic Acid (PLA) is one of biodegradable material that used in 3D printing technology. The objective of this study is to determine the optimum process parameters and the best combination of level process parameter for the 3D printing process of PLA part using Taguchi method. The experimental design being used in this research was the orthogonal arrays of L9 (34) that has 9 experiments with 4 process parameters (nozzle temperature, extrusion width, infill density and infill pattern) and 3 level on each process parameter. The responses in this research were dimension accuracy (LO, WO, w and T) and tensile strength of 3D printing PLA product, then data response result was analyzed using SNR and ANOVA. Based on SNR and ANOVA results that the most influencing of process parameters on the dimension accuracy response was dominated by nozzle temperature, and the tensile strength response was influenced by infill density followed by nozzle temperature. Based on the experiment confirmation for tensile strength response using the combination of the optimum level process parameter from Taguchi method, the results show that the tensile strength PLA parts significantly improve of 30.52 MPa at a confidence interval of 95%.