Coronary heart disease (CHD) is a progressive disease that continues to increase every year in Indonesia so it becomes a problem and threat to the community. CHD has several factors that affect the quality of life, both in terms of physical, social, psychological and environmental. The purpose of this research is to illustrate of domain WHOQOL-BREFF and SAQ-7 to the quality of life of CHD which is undergoing outpatient at RS Jogja hospital. This research is statistical descriptive research with cross-sectional approach taken by purposive sampling with 90 patients as respondents.The instrument used is SAQ-7 with 5 domains and WHOQOL-BREFF with 4 domains translated into the Indonesian language. The results of the study on the quality of life of CHD patients in RS Jogja hospital showed the high quality of life in 4 domains WHOQOL-BREF (97%) and 5 domains SAQ-7 (91%). Relation 4 WHOQOL-BREF domains on quality of life (physical health r = 0.696, psychological r = 0.870, social relation r = 0.730, environment r = 0.799) and the relationship of 5 SAQ-7 domains to quality of life (physical limitations r = 0.362 angina stability r = 0.757, angina frequency r = 0.806, treatment satisfaction r = 0.830, perception of disease r = 0.634). It can be concluded that psychological factors have a relationship that is most dominant.