Premenstrual syndrome (PMS) is cycle interference which happens to adolescents, the lack of knowledge is can aggravate about PMS make the adolescents have anxiety when they are getting PMS, it can be interfere adolescent activity. It should needs to be treatment, the one of PMS treatment is compressing the stomach with warm water, massage routine exercise in order to be health. Knowing the relationship of PMS knowledge with coping behavior in overcome the anxiety when the adolescent are was get PMS in SMPN 1 Kasihan Bantul. The kind of this research is analytic research to know the causing factor and relations between two variables with cross sectional approach. The research used random sampling methods with total of sample is 63 respondents while and bivariat analysis used spearman rank. Famel adolescents in SMPN 1 Kasihan Bantul majority have good category 52,4%. Then, coping behavior in overcome the anxiety when the famel students are was got PMS on moderate category 57,1%. The result of bivariat test prove that relations of PMS knowledge within coping behavior in overcome the anxiety with p value is 0,000. There is any significant relations between PMS knowledge with behavior coping in overcome the anxiety when the adolescent are was got PMS