This research aims at testing the influence of work stress towards work satisfaction and turnover intention of the staffs moderated by perceived organizational support. This research used Moderated Regression Analysis (MRA) to test the research hypothesis, with total sample of 73 staffs of Bank Muamalat Yogyakarta. The sample collection technique used saturation sampling. The result of the research shows that work stress has negative influence towards work satisfaction and has positive influence towards turnover intention. It means that the higher the level of work stress, the lower the work satisfaction. However, perceived organizational support cannot moderate the influence of work stress towards work satisfaction and turnover intention. It means perceived organizational support cannot decrease work stress that causes the increase of work satisfaction and the decrease of turnover intention. The work satisfaction increases because the appreciation of the leader and turnover intention decreases because of comfortable and happy feeling towards the work and it is not because of perceived organizational support