This study aims to analyze the factors that influence the interest in using e-commerce-based accounting information systems, study on Accounting Students in Faculty of Economics and Business Muhammadiyah University of Yogyakarta. The subjects in this study were 2015-2016 Accounting Students with certain criteria. In this study, sample of 92 respondents were selected using the purposive sampling method, the technique of taking samples in a non-random population and paying attention to the strata in the population so the sample will be more representative. Analysis tool used in this study is IBM Statistics SPSS 23. Based on the analysis that have been made, the results are variable Attitude does not have a positive influence on interest in using e-commerce-based accounting information system. While variable Subjective Norms, Perceived Behavioral Control, Perceived Usefulness, and Perceived Ease of Use have positive influence on the interest in using e-commerce-based accounting information system, study on 2015-2016 Accounting Students in Faculty of Economics and Business, Muhammadiyah University of Yogyakarta.